Malaga recorded a convincing 3-0 win over Granada, with Christian Atsu scoring a debut goal following his loan move from Chelsea.
Goals from Anthony Knockaert, Tomer Hemed and Jamie Murphy secured a third consecutive win for Brighton and Hove Albion.
Borussia Monchengladbach thrashed Werder Bremen 5-1, with defender Andreas Christensen - on loan from Chelsea - scoring twice.
Sergio Aguero and Jamie Vardy will go head to head this weekend and the Manchester City man had high praise for his fellow striker.
Luis Enrique will take charge of Barcelona for the 100th time against Levante on Sunday, and he could equal a Pep Guardiola club record.
Kevin Strootman scored a penalty for the Roma Primavera side as he made his first competitive appearance of the season.
Barcelona will use "all legal actions" to defend themselves amid allegations it was involved in the disclosure of trade secrets.
Title-chasing Juventus travel to Frosinone this weekend before their potentially decisive meeting with Serie A leaders Napoli in midweek.
Pep Guardiola must be wary of pressure to deliver unprecedented success at Manchester City, Manchester United's Ander Herrera has warned.
Louis van Gaal and Guus Hiddink's coaching rivalry spans three countries and 18 years, but the Chelsea boss was keen to play it down.
Real Madrid visit Granada boasting a formidable recent record but Youssef El-Arabi insists his side can surprise Zinedine Zidane's men.
Guus Hiddink says Chelsea will not risk loan striker Alexandre Pato before he has regained full fitness.
Sheikh Salman says he is "humbled" following CAF's announcement that they will support his candidacy to become FIFA president.
Benik Afobe's success since joining Bournemouth last month does not surprise Arsene Wenger, who must find a way to blunt his former striker.
After calling their form "sparkling", Louis van Gaal has challenged Manchester United to keep their title hopes alive by beating Chelsea.
AC Milan have made a fine start to 2016, but M'Baye Niang has warned against easing off as they prepare to welcome Udinese.
Angel Di Maria is ready for a heated reception when Paris Saint-Germain travel to Marseille for Le Classique.
Jackson Martinez's failure at Atletico Madrid was not down to a lack of effort or commitment, says boss Diego Simeone.
Arsene Wenger hopes to have Danny Welbeck fit within three weeks and the forward has made a successful return for the Arsenal Under-21 side.
Inter attacker Mauro Icardi wants his side to show what they are capable of when they travel to Verona at the weekend.