The Champions League final proved little distraction for Chelsea as they condemned Blackburn to a 2-1 defeat in their last Premier League game.
The west Londoners flew out of the blocks at Stamford Bridge, creating numerous openings in the first 25 minutes. However the deputising Jake Kean made an impressive start in the Rovers' goal and was at hand to keep the scores level.
A goal looked inevitable though, and did eventually come through John Terry after half an hour, while a second from Meireles following after a matter of minutes.
It was completely one-way traffic from there on in, with the hosts wasting several chances to add a third before the break.
The hosts started strongly in the second half too, nearly adding a third early on. However it was the visiting side that scored the next goal, Scott Dann heading into the back of the net.
Despite the setback, the home side managed to see out the win with ease.
Di Matteo made a number of changes for their final Premier League game of the season, with the Champions League final against Bayern Munich no doubt in mind.
With just a couple of minutes on the clock the hosts nearly found a breakthrough, however Florent Malouda's cross was scrambled away by Kean.
The exciting start continued as Blackburn then had a good chance, Jason Lowe's strike from outside the box taking a wicked deflection off Raul Meireles which forced Ross Turnbull to athletically tip it over.
Di Matteo's men hit back with two more decent attacks within the opening quarter-of-an-hour. Daniel Sturridge won a corner off Marcus Olsson, from which Romelu Lukaku got himself into a good position but headed wide.
Moments after, the Belgian forward then had another chance following a neat through-ball from Ramires, however Kean rushed out and timed his dive at the striker's feet perfectly.
Chelsea missed a couple more opportunities in front of goal before eventually finding the breakthrough on the half-hour when John Terry met Lukaku's cross from the right-flank with a powerful header, which Kean could do nothing to stop.
The flood gates then looked as if they might open, as the Blues wasted no time in doubling their lead. The Blackburn defence allowed Michael Essien too much space on the edge of their box, before the Ghanaian managed to shift the ball on to Meireles who found the back of the net with a low strike.
The already relegated side certainly seemed lacking in motivation, however the same cannot be said for the Blues as the onslaught on the visitors' goal continued.
Two minutes into the second period and Blackburn were under pressure once more. Firstly, Sturridge skilfully cut inside onto his right-foot and narrowly smashed an effort over the bar. Then, Lukaku advanced on the right-flank before beating his man, only to drag a poor effort wide.
Didier Drogba came on in place of the lively Lukaku, both receiving standing ovations from the Blues' fans at Stamford Bridge.
The game had quietened down after that, but out of nowhere Dann rose above Blues' goalscorer Terry to head home from a corner himself, making it 2-1.
Rovers started to look as if they could get something out of the game, Junior Hoilett beating a number of Chelsea shirts before firing over, then Drogba embarked on a powerful run, only to be denied a shot on goal by a last-ditch tackle by Dann.
The final 10 minutes saw the hosts have a few more half-chances, the likes of Fernando Torres and Sturridge attempted to penetrate the Blackburn area with no luck.
Then, in the final stages, both sides had chances to grab a late goal, however Turnbull threw himself at Olsson's cross to deny Rovers and Terry failed to get a proper connection on Drogba's delivery.